Mass Spectroscopy Core
J. Turk, Core Director
Publications 1997-2001
  1. Aguilar-Salinas CA, Barrett PHR, Pulai J, Zhu XL, & Schonfeld G. A familial combined hyperlipidemic kindred with impaired apolipoprotein B catabolism: kinetics of apolipoprotein B during placebo and pravastatin therapy. Arterio. Thromb. Vasc. Biol. 17:72-82 (1997).
  2. Albert CJ, Crowley J., Hsu FF, Thukkani AR, & Ford DA. Reactive chlorinating species produced by myeloperoxidase target the vinyl ether bond of plasmalogens: Identification of 2-chlorohexadecanal. J. Biol. Chem. 276: 23733-23741 (2001).
  3. Anderson MM, Hazen SL, Hsu FF, & Heinecke JW. Human neutrophils employ the myeloperoxidase-hydrogen peroxide-chloride system to convert hydroxy-amino acids into glycolaldehyde, 2-hydroxypropanal, and acrolein.... J. Clin. Invest. 99: 424-432 (1997).
  4. Anderson MM, Requena JR, Crowley JR, Thorpe SR, & Heinecke JW. The myeloperoxidase system of human phagocytes generates N-(carboxymethyl)lysine on proteins: A mechanism for producing advanced glycation end products at sites of inflammation. J. Clin. Invest. 104: 103-113 (1999).
  5. Appicelli PA, Lemon PWR, & Yarasheski KE. Protein kinetic and hormonal response to ingestion of different macronutrients following heavy resistance exercise. Med. Sci. Sports Exerc. 31: S125 (1999).
  6. Bergt C, Marsche G, Panzenboeck U, Heinecke JW, Malle E, & Sattler W. Human neutrophils employ the myeloperoxidase/hydrogen peroxide/chloride system to oxidatively damage apolipoproteinA-I. Eur. J. Biochem. 268: 3523-3521 (2001).
  7. Bernstein M, Jahoor F, Townsend C Jr, Klein S: Amino acid, glucose, and lipid kinetics after palliative resection in a patient with glucagonoma syndrome. Metabolism 2001; 50:720-722.
  8. Bhasin S, Storer T, Berman N, Yarasheski K, Clevenger B, Phillips J, Lee W, Bunnell T, & Casaburi R. Testosterone replacement increases fat-free mass and muscle size in hypogonadal men. J. Clin. Endocrinol. Metab. 82: 407-413 (1997).
  9. Bhasin S, Storer TW, Javanbakht M, Berman N, Yarasheski KE, Phillips J, Dike M, Sinha-Hikim I, Shen R, Hays RD, & Beall G. Testosterone replacement and resistance exercise in HIV-infected men with weight loss and low testosterone levels. J. Am. Med. Assoc. 283: 763-770 (2000).
  10. Bhattacharjee S, Pennathur S, Byun J, Crowley JR, Mueller D, Gischler J, Hotchkiss RS, & Heinecke JW. Neutophils employ the phagocyte NADPH oxidase to elevate 0,0’-dityrosine levels in proteins and urine during inflammation. J. Clin. Invest., under review (2001).
  11. Bier DM & Yarsheski KE. Protein metabolism in healthy elderly adults. In Amino Acid Metabolism in Health and Disease (Tessari P, ed.) (1997).
  12. Bohlin K, Merchak A, Patterson B, & Hamvas A. Surfactant turnover is faster in infants with normal lungs compared to infants with lung disease. Pediatr. Res., in press (2001).
  13. Bosner MS, Lange LG, Stenson WF, & Ostlund RE. Percent cholesterol absorption in normal women and men quantified with dual stable isotopic tracers and negative ion mass spectrometry. J. Lipid Res. 40: 302-308 (1999).
  14. Bosner MS, Wolff A, & Ostlund RE. Lack of effect of cholesterol esterase inhibitor CVT-1 on cholesterol absorption and LDL cholesterol in humans. Cardiovascular Drugs and Therapy 13: 449-454 (1999).
  15. Brennan ML, Anderson MM, Shih DM, Wang X, Mehta AC, Lim LL, Shi W, Hazen SL, Jacob JS, Crowley JR, Heinecke JW, & Lusis AL. Increased atherosclerosis in myeloperoxidase-deficient mice. J. Clin. Invest. 107: 419-430 (2001).
  16. Byun J, Henderson JP, Mueller DM, & Heinecke JW. 8-Nitro-2’-deoxyguanosine, a specific marker of oxidation by reactive nitrogen species, is generated by the myeloperoxidase-hydrogen peroxide-nitrite system of activated human phagocytes. Biochemistry 38: 2590-2600 (1999).
  17. Byun J, Mueller DM, Fabjan S, & Heinecke JW. Nitrogen dioxide radical generated by the myeloperoxidase-hydrogen peroxide-nitrite system promotes lipid peroxidation of low density lipoprotein. FEBS Lett. 455: 243-246 (1999).
  18. Campbell WW, Ostlund RE, Joseph LJ, Farrell PA, & Evans WJ. Relationships of plasma C-peptide and gender to the urinary excretion of inositols in older people. Horm. Metab. Res. 33: 44-51 (2001).
  19. Carpentier A, Patterson BW, Leung N, & Lewis GF. VLDL triglyceride production is predicted by body mass index (BMI) independent of direct measures of insulin sensitivity. Circulation, under review (2001).
  20. Carpentier A, Patterson BW, Uffelman KD, Bigam D, Steiner G, Cattral MS, & Lewis GF. VLDL-apoB production rates do not differ between pancreas transplant recipients with portal vs. systemic venous anastomosis. Diabetes 48 (suppl.1):A1 (1999).
  21. Carpentier A, Patterson BW, Uffelman KD, Giacca A, Vranic M, Cattral MS, & Lewis GF. The effect of systemic vs. portal insulin delivery in pancreas transplantation on glucose, fatty acid, and VLDL metabolism. Diabetes 50: 1402-1413 (2001).
  22. Caumo A, Vicini P, Zachwieja JJ, Avogaro A, Yarasheski KE, Bier DM, & Cobelli C. Minimal model estimate of glucose effectiveness: role of the minimal model volume and of the second hidden compartment. Am J. Physiol. 274: E573-576 (1998).
  23. Caumo A, Vicini P, Zachwieja JJ, Avogaro A, Yarasheski KE, Bier DM, Cobelli C: Undermodeling affects minimal model indexes: insights from a two-compartment model. Am J Physiol 1999; 276(Endocrinol Metab 39):E1171-E1193.
  24. Chait A & Heinecke JW. Lipoproteins, modified lipoproteins, and atherosclerotic vascular disease. In Lipoproteins in Health and Disease (Betteridge J, Illingsworth R, & Sheppard J, eds.), pp. 597-610 (1999).
  25. Chen D, Crimmins DL, Hsu FF, & Lindberg F. Hemoglobin Raleigh as the cause of a falsely elevated HBA1C in an automated ion-exchange HPLC method. Clin. Chem. 44: 1296-1301 (1998).
  26. Crowley J, Leeuwenburgh C, Yarasheski K, Turk J, and Heinecke J. Isotope dilution mass spectrometric measurement of 3-nitro-tyrosine is facilitated by reduction to 3-amino-tyrosine. Anal. Biochem., 1998; 259: 127-135.
  27. Davis A, Christiansen M, Horowitz JF, Klein S, Hellerstein MK, & Ostlund RE. Effect of pinitol treatment on insulin action in subjects with insulin resistance. Diabetes Care 23: 1000-1005 (2000).
  28. Davis A, Yarasheski KE, White NH, Canter C, & Marshall B. Glucocorticoids block the effect of insulin on hepatic glucose production in Rabson-Mendenhall Syndrome (RMS). Pediatric Research 43(Suppl. 2): 73 (1998).
  29. DeMattos RB, Brendza R, Heuser J, Kierson M, Fryer J, Fagan AM, Han X, & Holtzman DM. Purification and characterization of astrocyte-secreted apolipoprotein E and J containing lipoproteins from wild-type and human ApoE transgenic mice. Neurochem. Int., in press (2001).
  30. Elias N, Patterson BW, & Schonfeld G. Decreased production rates of VLDL triglycerides and apoB-100 in subjects heterozygous for familial hypobetaliproteinemia. Arterio. Thromb. Vasc. Biol. 19: 2714-2721 (1999).
  31. Elias N, Patterson BW, & Schonfeld G. In vivo metabolism of apoB, apoA-I and VLDL triglycerides in a form of hypobetalipoproteinemia not linked to the apoB gene. Arterio. Thromb. Vasc. Biol. 20: 1309-1315 (2000).
  32. Fowles JR, MacDougall JD, Tarnopolsky MA, Sale DG, Roy BD, & Yarasheski KE. The effects of acute passive stretch on muscle protein synthesis in humans. Can. J. Appl. Physiol. 25: 165-180 (2000).
  33. Fu X, Dean RT, Davies MJ, & Heinecke JW. Protein oxidation in atherogenesis. In Atherosclerosis (Dean RT & Kelly D, eds.), Oxford University Press, in press (2001).
  34. Fu X, Kassim S, Parks W, & Heinecke JW. Hypochlorous acid, a specific product of myeloperoxidase, oxygenates the cysteine switch domain of matrilysin. Implications for the role of oxidants in matrix metalloproteinase activation and rupture of the atherosclerotic plaque. J. Biol. Chem., under review (2001).
  35. Gaut J & Heinecke JW. Mechanisms for oxidizing low-density lipoprotein: Insights from patterns of oxidation products in the artery wall and from mouse models of atherosclerosis. Trends Cardio. Med., in press (2001).
  36. Ghomashchi F, Hefner Y, Ramanadham S, Turk J, Leslie CC, & Gelb MH. A pyrrolidine-based specific inhibitor of cytosolic phospholipase A2 blocks arachidonic acid release in a variety of mammalian cells. Biochim. Biophys. Acta, in press (2001).
  37. Gibala MJ, Interisano SA, Tarnopolsky MA, Roy BD, McDonald JR, Yarasheski KE, & MacDougall JD. Myofibrillar disruption following acute concentric and eccentric resistance exercise in strength-trained men. Can. J. Physiol. Pharmacol. 78: 656-66 (2000).
  38. Greiwe J, Cheng B, Rubin D, Yarasheski KE, & Semenkovich C. Resistance exercise decreases skeletal muscle tumor necrosis factor alpha in frail elderly humans. FASEB J. 15: 475-482 (2001).
  39. Hale CC, Ebeling EG, Hsu FF, & Ford DA. The selective activation of the cardiac sarcolemmal sodium-calcium exchanger by plasmalogenic phosphatidic acid produced by phospholipase D. FEBS Lett. 422: 247-251 (1998).
  40. Han X & Gross RW. Quantitative analysis and molecular species fingerprinting of triacylglycerol molecular species directly from lipid extracts of biological samples by electrospray ionization tandem mass spectrometry. Anal. Biochem., under review (2001).
  41. Han X, Abendschein DR, Kelley JG, & Gross RW. Diabetes-induced changes in specific lipid molecular species in rat myocardium. Biochem. J. 352: 79-89 (2000).
  42. Han X, Ramanadham S, Turk J, & Gross RW. Reconstitution of membrane fusion between pancreatic islet secretory granules and plasma membranes. Catalysis by a protein constituent recognized by a monoclonal antibody directed against glyceraldehyde-3-phosphate dehydrogenase. Biochim. Biophys. Acta 1414: 95-107 (1998).
  43. Han X. Direct quantitation of galactocerebroside molecular species from lipid extracts of brain tissues by electrospray ionization tandem mass spectrometry. J. Lipid Res., under review (2001).
  44. Hasten DL, Morris GS, Ramanadham S, & Yarasheski KE. Isolation of human skeletal muscle myosin heavy chain and actin for measurement of fractional synthesis rates. Am J. Physiol. 275: E1092-1099 (1998).
  45. Hasten DL, Pak-Loduca J, Obert KA, Yarasheski KE: Resistance exercise acutely increases MHC and mixed muscle protein synthesis rates in 78-84 and 23-32 yr olds. Am J Physiol 2000; 278:E620-E626.
  46. Hazen S.L., Hsu F.F., Gaut J.P., Crowley J.R., Heinecke J.W. Modification of proteins and lipids by myeloperoxidase. Meth. Enzym. 1999;300:88-105.
  47. Hazen SL & Heinecke JW. 3-Chlorotyrosine, a specific marker for myeloperoxidase-catalyzed halogenation, is present in human atherosclerotic aorta. J. Clin. Invest. 99: 2075-2081 (1997).
  48. Hazen SL, Crowley JR., Mueller DM, & Heinecke JW. Mass spectrometric quantification of 3-chlorotyrosine in human tissues with attamole sensitivity. A sensitive and specific marker for myeloperoxidase-catalyzed chlorination at sites of inflammation. Free Radical Biol. Med. 23: 909-916 (1997).
  49. Hazen SL, d’Avignon A, Anderson MM, Hsu FF, & Heinecke JW. Human neutrophils employ the myeloperoxidase-hydrogen peroxidase-chloride system to oxidize -amino acids to a family of reactive aldehydes: Mechanistic studies identifying labile intermediates along the reaction pathway. J. Biol. Chem. 273: 4997-5005 (1998).
  50. Hazen SL, Gaut JP, Crowley JR, Hsu FF, & Heinecke JW. Elevated levels of protein-bound p-hydroxyphenylacetaldehyde, an amino acid-derived aldehyde generated by myeloperoxidase, are present in human fatty streaks, intermediate lesions, and advanced atherosclerotic lesions. Biochemical J. 352: 693-699 (2000).
  51. Hazen SL, Gaut JP, Hsu FF, d’Avignon A, & Heinecke JW. Para-hydroxyphenylacetaldehyde, the major product of L-tyrosine oxidation by the myeloperoxidase-H2O2-chloride system of phagocytes, covalently modifies free amino groups of protein lysine residues. J. Biol. Chem. 272: 16990-16998 (1997).
  52. Hazen SL, Heller J, Hsu FF, d’Avignon A, & Heinecke JW. Synthesis, isolation, and characterization of the adduct formed in the reaction of p-hydroxyphenylacetaldehyde with the amino head group of phosphatidylethanolamine and phosphatidylserine. Chem. Res. Tox. 12: 19-27 (1999).
  53. Hazen SL, Hsu FF, d’Avignon A, & Heinecke JW. Human neutrophils employ myeloperoxidase to generate a battery of reactive aldehydes: A pathway for the generation of aldehydes at sites of inflammation. Biochemistry 37: 6864-6873 (1998).
  54. Heijligenberg R, Romijn JA, Klein S, Endert E, & Sauerwein HP. Lipolytic sensitivity to catecholamines in patients with Human Immunodeficiency Virus infection. Am. J. Clin. Nutr. 66 633-638 (1997).
  55. Heinecke J.W. Mechanisms of oxidative damage of low-density lipoprotein in human atherosclerosis. Curr. Opinions Lipid. 8: 268-274 (1997).
  56. Heinecke J.W.: Biochemical evidence for a link between elevated levels of homocysteine and lipid peroxidation in vivo. Cur. Athero. Reports. 1999;1:87-89.
  57. Heinecke J.W.: Is lipid peroxidation relevant to atherogenesis? J. Clin. Invest. 1999;104:135-136.
  58. Heinecke J.W.: Mass spectrometric quantification of amino acid oxidation products in proteins: Insights into pathways that promote LDL oxidation in the human artery wall. FASEB J. 1999;13:1113-1120.
  59. Heinecke J.W.: Protein chlorination in human atherosclerotic heart disease. In: The Natural Chemistry of Chlorine in the Environment. EuroChlor, 2nd Ed. 1999, pp 25-26.
  60. Heinecke J.W.: Unique aspects of sulfur chemistry: Homocysteine and lipid oxidation. In: Homocysteine in Health and Disease (Carmel R., Jacobsen D.W. eds). Cambridge University Press. In press.
  61. Heinecke JW, Hsu FF, Crowley JR, Hazen SL, Leeuwenburgh C, & Turk J. Detecting oxidative modification of biomolecules in vivo with isotope dilution mass spectrometry. Sensitive and quantitative assays for oxidized amino acids in proteins and tissues. Methods Enzymol. 300: 124-144 (1999).
  62. Heinecke JW. Mechanisms of oxidative damage by myeloperoxidase in atherosclerosis and other inflammatory diseases. J. Lab. Clin. Med. 133: 321-325 (1999).
  63. Heinecke JW. Oxidants and antioxidants in the pathogenesis of atherosclerosis: Implications for the oxidized low-density lipoprotein hypothesis. Atherosclerosis 141: 1-15 (1998).
  64. Heinecke JW. Pathways for oxidation of low-density lipoprotein by myeloperoxidase: Tyrosyl radical, reactive aldehydes, hypochlorous acid and molecular chlorine. BioFactors 6: 145-155 (1997).
  65. Heinecke JW. Pathways for oxidative tissue injury by myeloperoxidase. In The Peroxidase Multigene Family of Enzymes (Petrides PE & Nauseef WM, eds.), Springer-Verlag Publishing Co., pp. 102-107 (2000).
  66. Heinecke JW. Reaction pathways for oxidation of low density lipoprotein by the myeloperoxidase-hydrogen peroxide system of activated phagocytes. In Cardiovascular Disease in Older Persons (Kaiser FE, Morely JE, & Coe RM, eds), Springer Publ. Co., pp. 87-96 (1997).
  67. Heinecke JW. Sources of vascular oxidative stress. In Oxidative Stress and Vascular Disease (Keaney J, ed.), Kluwer Academic Press, pp. 9-26 (1999).
  68. Heinecke JW. The respiratory burst of neutrophils: Oxidative pathways for the initiation of tissue damage at sites of inflammation. In: The Neutrophil: New Outlook for Old Cells. (Gabrilovich D. Ed). Imperial College Press., pp 31-57 (1998).
  69. Heller JI, Crowley JR, Hazen SL, Salvay DM, Wagner P, Pennathur S, & Heinecke JW. p-Hydroxyphenylacetaldehyde, an aldehyde generated by myeloperoxidase, modifies phospholipid amino groups of low-density lipoprotein in human atherosclerotic intima. J. Biol. Chem. 275: 9957-62 (2000).
  70. Henderson J., Byun J, Mueller DM, & Heinecke JW. The eosinophil peroxidase-hydrogen peroxide-bromide system of human eosinophils generates 5-bromouracil, a mutagenic thymine analog. Biochemistry 40: 2052-2059 (2001).
  71. Henderson J.P., Byun J., and Heinecke J.W.: Molecular chlorine generated by the myeloperoxidase-hydrogen peroxide-chloride system of phagocytes produces 5-chlorocytosine in bacterial RNA. J. Biol. Chem. 1999;274:33440-33448.
  72. Henderson JP, Byun J, Williams MV, Mueller DM, McCormick M, Parks WC, Ridnour LA, & Heinecke JW. Bromination of deoxycytidine by eosinophil peroxidase: A mechanism for mutagenesis by oxidative damage of nucleotide precursors. Proc. Natl. Acad. Sci. 98: 1631-1636 (2001).
  73. Henderson JP, Byun J, Williams MV, Mueller DM, McCormick ML, & Heinecke J. Production of brominating intermediates by myeloperoxidase. A transhalogenation pathway for generating mutagenic nucleobases during inflammation. J. Biol. Chem. 276: 7867-7875 (2001).
  74. Henderson, J.P., Byun J., Heinecke J.W.: Chlorination of nucleobases, RNA and DNA by myeloperoxidase: a pathway for cytotoxicity and mutagenesis by activated phagocytes. Redox Reports. 1999;4:319-320.
  75. Hickner RC, Fisher JS, & Kohrt WM. Regional differences in interstitial glycerol concentration in subcutaneous adipose tissue of women. Am. J. Physiol. (Endocrinol. Metab. 36) 273: E1033-E1038 (1997).
  76. Horowitz JF & Klein S. Lipid metabolism during endurance exercise. Am. J. Clin. Nutr. 72: 558S-563S (2000).
  77. Horowitz JF & Klein S. Oxidation of non-plasma fatty acids during exercise is increased in women with abdominal obesity. J. Appl. Physiol. 89: 2276-2282 (2000).
  78. Horowitz JF & Klein S. Whole-body and abdominal lipolytic sensitivity to epinephrine is suppressed in women with upper-body obesity. Am. J. Physiol. (Endocrinol. Metab.) 278: E1144-E1152 (2000).
  79. Horowitz JF, Braudy R, Martin W, & Klein S. Endurance exercise training does not alter lipolytic or adipose tissue blood flow sensitivity to epinephrine. Am. J. Physiol. (Endocrinol. Metab.) 277: E325-E33 (1999).
  80. Horowitz JF, Coppack SC, Paramore D, Cryer PE, Braudy R, & Klein S. Effect of short-term fasting on lipid kinetics in lean and obese women. Am. J. Physiol. 276: E278-E284 (1999).
  81. Horowitz JF, Coppack SW, & Klein S. Whole body and adipose tissue glucose metabolism in response to short-term fasting in lean and obese women. Am. J. Clin. Nutr. 73: 517-522 (2001).
  82. Hsu FF & Turk J. Characterization of phosphatidylinositol, phosphatidylinositol-4-phosphate, and phosphatidylinositol-4,5-bisphosphate by electrospray ionization tandem mass spectrometry. A mechanistic study. J. Am. Soc. Mass Spectrom. 11: 986-999 (2000).
  83. Hsu FF & Turk J. Charge-driven fragmentation processes in diacyl glycerophosphatidic acids upon low-energy collisional activation. A mechanistic proposal. J. Am. Soc. Mass Spectrom. 11: 797-803 (2000).
  84. Hsu FF & Turk J. Charge-remote and charge-driven fragmentation processes in diacyl glycerophosphoethanolamine upon low-energy collisional activation: A mechanistic proposal. J. Am. Soc. Mass Spectrom. 11: 892-899 (2000).
  85. Hsu FF & Turk J. Distinction among isomeric unsaturated fatty acids as lithiated adducts by electrospray ionization mass spectrometry using low energy collisionally activated dissociation on a triple stage quadrupole instrument. J. Am. Soc. Mass Spectrom. 10: 600-613 (1999).
  86. Hsu FF & Turk J. Structural characterization of triacylglycerols as lithiated adducts by electrospray ionization mass spectrometry using low energy collisionally activated dissociation on a triple stage quadrupole instrument. J. Am. Soc. Mass Spectrom. 10: 587-600 (1999).
  87. Hsu FF & Turk J. Structural determination of glycerophosphoethanolamine as a lithiated adduct by tandem mass spectrometry with electrospray ionization. J. Mass Spectrom. 35: 595-606 (2000).
  88. Hsu FF & Turk J. Structural determination of glycosphingolipids as lithiated adducts by electrospray ionization mass spectrometry using low energy collisionally activated dissociation on a triple stage quadrupole instrument. J. Am. Soc. Mass Spectrom. 12: 61-79 (2001).
  89. Hsu FF & Turk J. Structural determination of sphingomyelin by tandem mass spectrometry with electrospray ionization. J. Am. Soc. Mass Spectrom. 11: 437-449 (2000).
  90. Hsu FF & Turk J. Studies on phosphatidylglycerol with triple quadrupole mass spectrometry with electrospray ionization. Fragmentation processes and structural characterization. J. Am. Soc. Mass Spectrom. 2001; 12: 1036-1043.
  91. Hsu FF & Turk J. Tandem quadrupole mass spectrometry of sphingomyelin and sulfatides. In The Encyclopedia of Mass Spectrometry. Applications in Biochemistry, Biology, and Medicine. Part A (Caprioli R & Gross ML, eds.), Elsevier Science, New York, in press (2001).
  92. Hsu FF, Bohrer A, & Turk J. Electrospray ionization tandem mass spectrometric analysis of sulfatide. Determination of fragmentation patterns and characterization of sulfatide molecular species expressed in brain and pancreatic islets. Biochim. Biophys. Acta 1392: 202-216 (1998).
  93. Hsu FF, Bohrer A, & Turk J. Formation of lithiated adducts of glycerophospohcholine lipids facilitates their identification by electrospray ionization tandem mass spectrometry. J. Am. Soc. Mass Spectrom. 9: 516-526 (1998).
  94. Hsu FF, Bohrer A, Wohltmann M, Ramanadham S, Ma Z, Yarasheski K, & Turk J. Electrospray ionization mass spectrometric analyses of changes in tissue phospholipidmolecular species during the evolution of hyperlipidemia and hyperglycemia in Zucker diabetic fatty fats. Lipids 2000; 35: 839-854.
  95. Hsu FF, Giblin D, Hazen SL, Turk J, Heinecke J, and Gross ML. Mass spectrometric analysis of pentafluorobenzyl oxime derivatives of biological aldehydes. Int. J. Mass Spectrometry 1999; 185/186/187: 795-812.
  96. Hsu FF, Ma Z, Wohltmann M, Bohrer A, Ramanadham S, & Turk J. Electrospray ionization mass spectrometric analysis of human promonocytic U937 cell glycerolipids and evidence that differentiation is associated with membrane lipid composition changes that facilitate phospholipase A2 activation. J. Biol. Chem. 2000; 275: 16579-16589.
  97. Hsu FF, Turk J, Stewart ME, & Downing DT. Characterization of human epidermal ceramides by low energy collisionally activated dissociation tandem mass spectrometry with electrospray ionization. Submitted to J. Lipid Res. (2001).
  98. Hunt JH, Rossi AM, Holmberg NJ, Smith SR, & Sherman WR. Nutrients in social wasp honey. Ann. Entomol. Soc. Am. 91: 466-472 (1998).
  99. Ido Y & Williamson JR. Hyperglycemic cytosolic reductive stress pseudohypoxia. Implications for diabetic retinopathy. Invest. Ophthalmol. Vis. Sci. 38: 1467-1470 (1997).
  100. Ido Y & Williamson JR. The vascular cellular consequences of hyperglycemia. In Diabetic Angiopathy (Tooke JE, ed.), Chapman & Hall, London (1998).
  101. Ido Y, Kilo C, & Williamson JR. Cytosolic NADH/NAD+, free radicals, and vascular dysfunction in early diabetes mellitus. Diabetologia 40: S115-117 (1997).
  102. Joseph LJO, Trappe TA, Farrell PA, Campbell WW, Yarasheski KE, Lambert CP, & Evans WJ. Effects of short-term, moderate weight loss and resistance training on insulin action in postmenopausal women. J. Appl. Physiol., under review (2001).
  103. Judd RL, Nelson R, Klein S, Jensen MD, & Miles JM. Measurement of plasma glycerol specific activity by high performance liquid chromatography to determine glycerol flux. J. Lipid Res. 39: 1106-1110 (1998).
  104. Kawamura M, Heinecke JW, & Chait A. Increased uptake of alpha-hydroxy aldehyde modified low density lipoprotein by macrophage scavenger receptors. J. Lipid Res. 41: 1054-9 (2000).
  105. Kirk EA, Dinauer MC, Rosen H, Chait A, Heinecke JW, & LeBoeuf RC. Impaired superoxide production due to deficiency in phagocyte NADPH oxidase fails to inhibit atherosclerosis in mice. Arterio. Thromb. Vasc. Biol. 20: 1529-35 (2000).
  106. Kirwan JP, O’Gorman DJ, Cyr-Campbell D, Campbell WW, Yarasheski KE, & Evans WJ. Effects of a pre-exercise moderate glycemic meal on exercise duration and substrate utilization. Med. Sci. Sports Exerc., in press (2001).
  107. Klein S. The war against obesity: attacking a new front. Am. J. Clin. Nutr. 69: 1061-1063 (1999).
  108. Krut LH, Yang JW, Schonfeld G, & Ostlund RE. The effect of oxidizing cholesterol on gastrointestinal absorption, plasma clearance, tissue distribution and processing by endothelial cells. Arterioscler. Thromb. Vasc. Biol. 17: 778-785 (1997).
  109. Kulcharyk PA & Heinecke JW. Hypochlorous acid produced by the myeloperoxidase system of human phagocytes induces covalent crosslinks between DNA and protein. Biochemistry 40: 3648-3656 (2001).
  110. Kwon G, Corbett JA, Hauser S, Hill JR, Turk J, McDaniel ML: Evidence for the involvement of the proteasome complex (26S) and NF-kB in IL-1-induced nitric oxide and prostaglandin production by rat islets and RINm5F cells. Diabetes 1998; 47:583-591.
  111. Latour MA, Patterson BW, Kitchens RT, Ostlund RE, Hopkins D, & Schonfeld G. Effects of alcohol and cholesterol feeding on lipoprotein metabolism and cholesterol absorption in rabbits. Arterio. Thromb. Vasc. Biol. 19: 598-604 (1999).
  112. Latour MS, Patterson BW, Pulai J, Chen Z, & Schonfeld G. Metabolism of apolipoprotein B-100 in a kindred with familial hypobetalipoproteinemia without a truncated form of apoB. J. Lipid Res. 38: 592-599 (1997).
  113. Leeuwenburgh C & Heinecke JW. Oxidative stress and antioxidants in exercise. Current Medicinal Chemistry 8: 829-838 (2001).
  114. Leeuwenburgh C, Hansen P, Shaish A, Holloszy JO, & Heinecke JW. Markers of protein oxidation by hydroxyl radical and reactive nitrogen species in tissues of aging rats. Am. J. Physiol. 274: R453-R461 (1998).
  115. Leeuwenburgh C, Hansen PA, Holloszy JO, & Heinecke JW. Oxidized amino acids in the urine of aging rats: Potential markers for assessing oxidative stress in vivo. Am. J. Physiol. 276: R128-135 (1999).
  116. Leeuwenburgh C, Hansen PA, Holloszy JO, Heinecke JW. Hydroxyl radical generation during exercise increases mitochondrial protein oxidation and levels of urinary dityrosine. Free Radical Biol. Med. 27: 186-192 (1999).
  117. Leeuwenburgh C, Hardy MM, Hazen SL, Wagner P, Oh-ishi S, Steinbrecher UP, & Heinecke JW. Reactive nitrogen intermediates promote low-density lipoprotein oxidation in human atherosclerotic intima. J. Biol. Chem. 272: 1433-1436 (1997).
  118. Leeuwenburgh C, Rasmussen JE, Hsu FF, Mueller DM, Pennathur S, & Heinecke JW. Mass spectrometric quantification of markers for protein oxidation by tyrosyl radical, copper, and hydroxyl radical in low-density lipoprotein isolated from human atherosclerotic lesions. J. Biol. Chem. 272: 3520-3526 (1997).
  119. Leeuwenburgh C, Wagner P, Holloszy J, Sohal RS, & Heinecke JW. Caloric restriction attenuates dityrosine cross-linking of cardiac and skeletal muscle proteins in aging mice. Arch. Biochem. Biophys. 346:74-80 (1997).
  120. Lemieux S, Patterson BW, Carpentier A, Lewis GF, & Steiner G. Comparison of stable and radioactive isotopic methods to evaluate triglyceride kinetics in humans. Diabetes 48 (suppl. 1): A251 (1999).
  121. Lemieux S, Patterson BW, Carpentier A, Lewis GF, & Steiner G. A stable isotope method using a [2H5]-glycerol bolus to measure VLDL-TG kinetics in humans. J. Lipid Res. 40: 2111-2117 (1999).
  122. Lemon PW, Dolny DG, & Yarasheski KE. Moderate physical activity can increase dietary protein needs. Can. J. Appl. Physiol. 22: 494-503 (1997).
  123. Lim V, Wolfson M, Yarasheski KE, Flanigan MJ, & Kopple JD. Leucine turnvover in patients with nephrotic syndrome. Evidence suggesting body protein conservation. J. Am. Soc. Nephrol. 9: 1067-1073, (1998).
  124. Lim VS & Kopple JD. Protein metabolism in patients with chronic renal failure: role of uremia and dialysis. Kidney Int. 58: 1-10 (2000).
  125. Lim VS, Yarasheski KE, & Flanigan MJ. The effect of uremia, acidosis and dialysis treatment on protein metabolism: a longitudinal leucine kinetic study. Nephrology, Dialysis and Transplantation 13: 1723-1728 (1998).
  126. Lopate G, Kornberg MB, Yue J, Hsu FF, Choksi R, & Pestronk A. Antimyelin glycoprotein antibodies: Variability in patterns of IgM binding to peripheral nerve and correlations with selective binding to sulfatide fractions. Muscle and Nerve, in press (2001).
  127. Ma Z & Turk J. The molecular biology of the Group VIA Ca2+-independent phospholipase A2. Progr. Nucl. Acid Res. Molec. Biol., volume 67, in press (2001).
  128. Ma Z, Bohrer A, Wohltmann M, Ramanadham S, Hsu FF, & Turk J. Studies of phospholipid metabolism, proliferation, and secretion of stably transfected insulinoma cells that overexpress Group VIA Phospholipase A2. Lipids 36: 689-700 (2001).
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